Ertapenem for the treatment of bloodstream infections due to ESBL-producing Enterobacteriaceae: a multinational pre-registered cohort study

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Efficacy of ertapenem for treatment of bloodstream infections caused by extended-spectrum-β-lactamase-producing Enterobacteriaceae.

Ertapenem is active against extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae organisms but inactive against Pseudomonas aeruginosa and Acinetobacter baumannii. Due to a lack of therapeutic data for ertapenem in the treatment of ESBL bloodstream infections (BSIs), group 2 carbapenems (e.g., imipenem or meropenem) are often preferred for treatment of ESBL-producing Enterobacteria...

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Role of empirical and targeted therapy in hospitalized patients with bloodstream infections caused by ESBL-producing Enterobacteriaceae.

BACKGROUND Bloodstream infection (BSI) due to extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae are a major cause of in-hospital mortality. The effect on survival of empirical and targeted antibiotic therapy in these patients remains controversial. METHODS A prospective cohort study was conducted analyzing data from 94 patients (age 59 ± 21 years) with BSI due to ESBL producin...

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341Heterogeneous regional distribution of nosocomial infections due to ESBL-producing Enterobacteriaceae in Germany: Data from the German National Reference Center for the Surveillance of Nosocomial Infections (KISS)

341. Heterogeneous regional distribution of nosocomial infections due to ESBL-producing Enterobacteriaceae in Germany: Data from the German National Reference Center for the Surveillance of Nosocomial Infections (KISS) Rasmus Leistner, MD; Christin Schröder; Christine Geffers, MD; AnnChristin Breier, MD; Petra Gastmeier, MD; Michael Behnke, PhD; Institute of Hygiene and Environmental Medicine, ...

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 2016

ISSN: 0305-7453,1460-2091

DOI: 10.1093/jac/dkv502